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NSC 65809

CAS No. 94023-67-3

NSC 65809( 3-[(2,3-dichlorophenyl)methylene]carbazamidine )

Catalog No. M22219 CAS No. 94023-67-3

Raphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.

Raphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NSC 65809
  • Note
    Research use only, not for human use.
  • Brief Description
    Raphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.
  • Description
    Raphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitmentRaphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    3-[(2,3-dichlorophenyl)methylene]carbazamidine
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    R15B
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    94023-67-3
  • Formula Weight
    231.08
  • Molecular Formula
    C8H8Cl2N4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    NC(=N)N/N=C/c1cccc([Cl])c1[Cl]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Agnieszka Krzyzosiak, Anna Sigurdardottir, Laura Luh.et al.Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.Cell. 2018 Aug 23;174(5):1216-1228.e19.
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